Table 5.
Association of reversible metabolites with smoking status change in the prospective dataset (KORA S4 → F4)
| β estimate of smoking status (95% confidence interval) |
P | |
|---|---|---|
| Men | ||
| Arginine | -0.12 (-0.18, -0.06) | 1.4e-04a |
| Ornithine | -0.16 (-0.24, -0.08) | 2.1e-04a |
| PC aa C34:1 | -0.09 (-0.15, -0.03) | 3.3e-03a |
| PC aa C36:0 | 0.17 (0.09, 0.25) | 6.4e-05a |
| PC aa C36:1 | -0.12 (-0.18, -0.05) | 8.5e-04a |
| PC aa C38:0 | 0.14 (0.06, 0.22) | 3.0e-04a |
| PC aa C38:3 | -0.04 (-0.11, 0.02) | 1.7e-01 |
| PC aa C40:4 | -0.11 (-0.18, -0.03) | 6.0e-03 |
| PC ae C34:3 | 0.14 (0.06, 0.21) | 3.5e-04a |
| PC ae C38:0 | 0.13 (0.05, 0.21) | 1.8e-03a |
| PC ae C38:6 | 0.11 (0.04, 0.18) | 1.5e-03a |
| PC ae C40:6 | 0.08 (0.01, 0.15) | 2.1e-02 |
| lysoPC a C18:2 | 0.03 (-0.06, 0.11) | 5.2e-01 |
| Women | ||
| Carnitine | -0.12 (-0.20, -0.05) | 1.4e-03 |
| PC aa C32:1 | -0.18 (-0.32, -0.03) | 2.1e-03 |
| PC aa C36:1 | -0.11 (-0.20, -0.02) | 2.0e-02 |
| PC ae C34:3 | 0.09 (-0.02, 0.19) | 0.95 |
| SM (OH) C22.2 | 0.12 (0.02, 0.22) | 1.9e-02 |
Result of smoking status on metabolite concentrations using linear mixed model for S4 → F4 longitudinal data, adjusted for age, BMI, and alcohol consumption. PC: phosphatidylcholine; aa: diacyl-; ae: acyl-alkyl-; lysoPC: acyl-phosphatidylcholine; SM (OH): hydroxysphingomyeline. a FDR<0.05.