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. 2013 Apr 10;105(10):694–700. doi: 10.1093/jnci/djt045

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Published by Oxford University Press 2013.

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Figure 2. — Centered mean methylation values for 250 differentially methylated CpGs (dmCpGs) and time to diagnosis (TTD). A) Centered mean methylation β values in blood for the 250 dmCpGs for case subjects (blue) and noncase subjects (green) were obtained by subtracting the overall (case subjects + noncase subjects) mean from the mean for case subjects or from the mean for noncase subjects. Thus the vertical distance between green and blue dots represents the difference in means between case subjects and noncase subjects. dmCpGs are ordered from those where case subjects are the most undermethylated relative to noncase subjects on the left to those where case subjects are overmethylated relative to noncase subjects on the right. Black bars at the bottom of the figure indicate dmCpGs at CpG nonisland locations. B) Same centering as panel A but separating case subjects into two groups: case subjects with TTD greater than 1year (blue) and case subjects with TTD within 1 year (red triangle). Case subjects with TTD greater than 1 year tend to have intermediate values between the other two groups more than would be predicted by chance (P = 1.33×10⁻⁹).