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. 2013 May 14;8(5):e63904. doi: 10.1371/journal.pone.0063904

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Horizontal-sectional 2D-view OCT images of GCL-IPL, INL-ONL-PRL, or RPE-CH in comparison with color fundus photographs at different stages of EAU: a, normal retinal structure; b, onset of EAU (13 days post immunization), horizontal-sectional OCT images showed swelling vessels and peri-vascular exudates (green arrows) in the layer of GCL-IPL; c, acute phase of EAU (18 days post immunization), peri-vascular exudates in GCL-IPL layer, retinal folds (yellow arrows) and subretinal hemorrhage (asterisk) seen in INL-ONL-PRL layer were detected by OCT 3D-view rectangle scanning; d, resolution phase of EAU (28 days post immunization), OCT detected a ring-like retinal thinning (yellow arrows) around the optic nerve head formed through INL-ONL-PRL; e, late phase of EAU (8 weeks post immunization), extensive ring-like retinal atrophy (arrows) in INL-ONL-PRL. Note parallel clinical features in the fundus images. Data are representative of 13 mice from two individual experiments.