Figure 4. Serial ERG response after dark and light adaptation in comparison to disease severity and fold change of retinal thickness obtained by OCT imaging.

EAU was induced in B10RIII mice by active immunization with IRBP161–180 in CFA. Mice were monitored and followed up at the indicative time points by standard fundoscopy, OCT and ERG. A, EAU clinical scores as determined by clinical examination using standard fundoscopy. B, Fold change of retinal thickness measured by OCT. C, Dark- and light-adapted ERGs during EAU. Data are present as mean ± SEM of 13 mice from two individual experiments. Statistical analyses of retinal thickness are performed using the Mann-Whitney test. *, p<0.05; **, p<0.01.