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. 2013 May 14;8(5):e64296. doi: 10.1371/journal.pone.0064296

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© 2013 La Torre et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Telomerase activity significantly correlates with h-TERT mRNA expression and WHO in astroglial brain tumors. The h-TERT expression levels in GBMs resulted statistically higher as compared with those in LGAs. The expressions in AAs differed significantly as compared with that in LGAs. A correlation was found between h-TERT and WHO grading (p<.001). Telomerase activity is expressed as relative telomerase activity (RTA) according to the formula showed in the methods. Error bars indicate standard deviation. * p<.05; ** p<.001. Abbreviations: NBT: normal brain tumor; LGA: Low grade Astrocytoma; AA: Anaplastic Astrocytoma; GBM: Glioblastoma Multiforme; h-TERT human telomerase reverse transcriptase.