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. 2013 May 14;8(5):e64324. doi: 10.1371/journal.pone.0064324

Table 1. Effects of δ/ω-PLTX-Pt1a (20 nM) on the voltage-dependent Na+ currents.

Vth (mV)a Vh (mV)b Ip (nA)c Iss (nA)c Ip/Iss ♦ (ms)d r (%)e
Before −38.6±9.0 −45.5±7.6 −1.43±0.64 −0.15±0.12 25.9±25.1 1.84±0.34 0.76±0.06
After −45.7±9.7* −50.0±5.4 −1.18±0.66 −0.22±0.15 9.2±9.4 3.44±1.58** 0.79±0.08
n = 7 n = 4 n = 7 n = 7 n = 6 n = 14 n = 4

Results are shown as Mean±SD. * p<0.01. **p<0.002. (Paired student's t-test).

a. Vth is the threshold membrane potential at which the amplitude of inward Na+ current is larger than 50 pA which can be confidently distinguished from the noise level;

b. Vh is the membrane potential of half-inactivation;

c. Ip and Iss are the amplitudes of peak and steady-state Na+ currents respectively;

d. ♦is the decay rate of the inactivating Na+ current evoked by depolarizing pulse to −20 mV from the holding potential of −80 mV. The value was obtained by single exponential fitting of the current decay phase. In 2 of the 14 cells, currents were better fitted with a double-exponential function, of which ♦1 was shown here.

e. r is the fractional recovery from inactivation of Na+ currents at −10 mV, assessed by the double pulse paradigm with an interpulse interval of 500 ms.