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. 2013 May 14;8(5):e64078. doi: 10.1371/journal.pone.0064078

Figure 5. Rapamycin reduces neuronal degeneration in hippocampus following TBI.

Figure 5

Representative sections of Fluoro-Jade B staining in different regions of hippocampus of control mice (Ctrl, A–C), vehicle-treated TBI mice (TBI+Veh, D–F) and rapamycin-treated TBI mice (TBI+Rap, G–I) three days after CCI are shown. Abundant Fluoro-Jade B positive neurons are seen in vehicle-treated TBI mice in CA1, CA3 and DG, but to a lesser degree in rapamycin-treated TBI mice. Quantitative analysis showed a significant decrease in Fluoro-Jade B positive cells in rapamycin-treated compared to vehicle-treated TBI mice (J–L). *p<0.05 by one-way ANOVA, n = 6 mice per group.