Table 1. Sequence characterisation of HeV siRNAs and D-siRNAs targeting N, P and M genes.

Identifier	Sense 5′–3′	Antisense 5′–3′
siN4	CUGAAGACUGCACGUGAAAUU	UUUCACGUGCAGUCUUCAGUU
siN5	GGACUGAGGAUCACCGAUAUU	UAUCGGUGAUCCUCAGUCCUU
siN6	AGAGGGUCAAUCCAUUCUUUU	AAGAAUGGAUUGACCCUCUUU
siN7	GGTAAAGAAAGGCGGAUCAUU	UGAUCCGCCUUUCUUUACCUU
siN8	AGGAAAUUAUGUCGAGGAAUU	UUCCUCGACAUAAUUUCCUUU
siN11	ACAUCAUGCUGGCGGGAUUUU	AAUCCCGCCAGCAUGAUGUUU
siN12	CAUGCAGGCAAGAGAAGCCUU	GGCUUCUCUUGCCUGCAUGUU
siN15	GCACAGAGCUCAUCGGAAAUU	UUUCCGAUGAGCUCUGUGCUU
siP2	CAACCAAGUACCAAAGACAGGACaa	UUGUCCUGUCUUUGGUACUUGGUUGUU
siP8	GGAGUAUGAGGAUGAGUUUGCCAaa	UUUGGCAAACUCAUCCUCAUACUCCAG
siP10	AGAAGAAACUCCUGAUGUACGCAga	UCUGCGUACAUCAGGAGUUUCUUCUUU
siP18	AGGCAAGGGUGAAAGGAAAGGGAaa	UUUCCCUUUCCUUUCACCCUUGCCUUU
siM2	GCCAGAAAUUGAUAAGCAUGGCAgt	ACUGCCAUGCUUAUCAAUUUCUGGCUC
siM5	CUCUUACCAUGGAAGAAGAUUCUga	UCAGAAUCUUCUUCCAUGGUAAGAGAU
siM7	CGACAAAGACGGAACCAAAGUGGca	UGCCACUUUGGUUCCGUCUUUGUCGAA
siM8	AGAGAAAGAUUGACAGAAUGAAGct	AGCUUCAUUCUGUCAAUCUUUCUCUUG
ScrM7	CGUUAAUCGCGUAUAAUACGCGUat	AUACGCGUAUUAUACGCGAUUAACGAC

Nucleocapsid siRNAs are conventional 21 bp siRNAs. All M, P and ScrM7 are D-siRNAs that are 25+27 bp long, with a two RNA nucleotide overhang only on the antisense strand and two DNA nucleotides on the sense strand depicted in lowercase letters.