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. 2013 May 14;8(5):e64486. doi: 10.1371/journal.pone.0064486

Figure 1. L-4F reduces mortality in endotoxemic rats.

Figure 1

Rat survival at 24 h following LPS (30 mg/kg, i.p., n = 26) versus rats treated by L-4F (10 mg/kg) administered either simultaneously with LPS as a premix (i.p., n = 20) or one hour after LPS (L-4F given i.v., n = 26). Saline only (n = 10) did not get either LPS or L-4F. Log-rank analysis indicates a significant trend in rat survival changes among groups (P<0.005) *P<0.05 vs. LPS, †P<0.05 vs. Saline (sham), ‡P<0.05 vs. L-4F one hour post LPS.