Figure 1. Kaplan Meier curves for the four strains of mice used in this study.

Each graph represents a comparison between two cohorts. A pairwise log-rank test was performed for all graphs to determine whether there are significant lifespan differences between the cohorts plotted in each graph. P-values are shown in the upper right corner. A. Within each specific mouse background strain (FVB or BALB/c+) we compared the MMTV-infected wild-type cohort with the infected genetically engineered line (either Pten heterozygous for the FVB cohort or Trp53 deficient for the BALB/c+ cohort). B. The difference in lifespan between the two wild-type strains is shown here.