Figure 5. The histological tumorigenic properties of β-cat^Δ/Δ ESCs can be restored to wild-type ESCs.

β-cat^fl/fl teratomas consisted of well-differentiated mesodermal tissues (bone and cartilage), endodermal tissues (glandular epithelial structures) and ectodermal tissues (pigmented cells). β-catenin-rescued β-cat^Δ/Δ mESCs (res-β-cat^Δ/Δ mESCs) gave rise to multilineage differentiated teratoma possessing mesoderm (bone and cartilage), endoderm (glandular epithelial structures) and ectoderm (epidermal tissue). Scale bars are 100 µm.