Table 2. Genotype and allele distribution of TLR -1, -2, and -6 polymorphisms in TB and controls.
SNP | Study | Case | Control | HWE | |||||||||
GG | GT | TT | G | T | GG | GT | TT | G | T | X2 | P | ||
TLR1 | Ma, et al. | 510 | 32 | 1 | 1052 | 34 | 509 | 34 | 1 | 1052 | 36 | 0.294 | 0.588 |
G1805T | Ma, et al. _a | 4 | 63 | 272 | 71 | 607 | 13 | 61 | 120 | 87 | 301 | 1.795 | 0.180 |
(rs5743618) | Ma, et al. _b | 107 | 61 | 12 | 275 | 85 | 63 | 33 | 14 | 159 | 61 | 6.956 | 0.008 |
Ma, et al. _c | 20 | 83 | 272 | 123 | 627 | 14 | 39 | 61 | 67 | 161 | 3.518 | 0.061 | |
Salvaraj et al. | 1 | 9 | 192 | 11 | 393 | 0 | 16 | 189 | 16 | 394 | 0.338 | 0.561 | |
Uciechowski et al. | 36 | 5 | 4 | 77 | 13 | 24 | 19 | 6 | 67 | 31 | 0.525 | 0.469 | |
TT | TC | CC | T | C | TT | TC | CC | T | C | X2 | P | ||
TLR2 | Thuong et al. | 177 | 138 | 35 | 492 | 208 | 205 | 154 | 18 | 564 | 190 | 2.633 | 0.105 |
T597C | Etokebe et al. | 66 | 84 | 40 | 216 | 164 | 162 | 244 | 83 | 568 | 410 | 0.298 | 0.585 |
(rs3804099) | Ma, et al. _a | 46 | 165 | 128 | 257 | 421 | 29 | 100 | 65 | 158 | 230 | 0.889 | 0.346 |
Ma, et al. _b | 55 | 90 | 35 | 200 | 160 | 41 | 47 | 22 | 129 | 91 | 1.562 | 0.211 | |
Ma, et al. _c | 133 | 191 | 51 | 457 | 293 | 18 | 80 | 16 | 116 | 112 | 18.601 | 0.000 | |
Sanchez, et al. | 173 | 220 | 72 | 566 | 364 | 95 | 153 | 52 | 343 | 257 | 0.514 | 0.473 | |
Che, et al. | 52 | 54 | 9 | 158 | 72 | 68 | 68 | 20 | 204 | 108 | 0.214 | 0.644 | |
TT | TC | CC | T | C | TT | TC | CC | T | C | X2 | P | ||
TLR2 | Che, et al. | 60 | 48 | 7 | 168 | 62 | 79 | 61 | 16 | 219 | 93 | 0.670 | 0.413 |
T1350C | Chen, et al. | 131 | 45 | 8 | 307 | 61 | 121 | 55 | 8 | 297 | 71 | 0.297 | 0.586 |
(rs3804100) | Etokebe, et al. | 159 | 26 | 1 | 344 | 28 | 483 | 67 | 1 | 1033 | 69 | 0.709 | 0.400 |
Ma, et al. _a | 299 | 38 | 2 | 636 | 42 | 169 | 25 | 0 | 363 | 25 | 0.920 | 0.337 | |
Ma, et al. _b | 151 | 24 | 5 | 326 | 34 | 101 | 9 | 0 | 211 | 9 | 0.200 | 0.655 | |
Ma, et al. _c | 312 | 62 | 1 | 686 | 64 | 100 | 14 | 0 | 214 | 14 | 0.488 | 0.485 | |
GG | GA | AA | G | A | GG | GA | AA | G | A | X2 | P | ||
TLR2 | Ogus, et al. | 124 | 13 | 14 | 261 | 41 | 107 | 7 | 2 | 221 | 11 | 12.783 | 0.000 |
G2258A | Ma, et al. _a | 337 | 2 | 0 | 676 | 2 | 194 | 0 | 0 | 388 | 0 | / | / |
(rs5743708) | Ma, et al. _b | 171 | 9 | 0 | 351 | 9 | 105 | 5 | 0 | 215 | 5 | 0.059 | 0.807 |
Ma, et al. _c | 374 | 1 | 0 | 749 | 1 | 110 | 4 | 0 | 224 | 4 | 0.036 | 0.849 | |
Jin, et al. | 99 | 71 | 0 | 269 | 71 | 168 | 31 | 0 | 367 | 31 | 1.420 | 0.233 | |
Yu | 76 | 1 | 0 | 153 | 1 | 75 | 0 | 0 | 150 | 0 | / | / | |
Salvaraj, et al | 192 | 1 | 0 | 385 | 1 | 198 | 1 | 0 | 397 | 1 | 0.001 | 0.972 | |
Sanchez, et al. | 463 | 3 | 0 | 929 | 3 | 296 | 4 | 0 | 596 | 4 | 0.014 | 0.907 | |
Xue, et al. | 204 | 1 | 0 | 409 | 1 | 202 | 1 | 0 | 405 | 1 | 0.001 | 0.972 | |
Ma, et al. | 543 | 0 | 0 | 1086 | 0 | 544 | 0 | 0 | 1088 | 0 | / | / | |
Dalgic, et al. | 93 | 31 | 0 | 217 | 31 | 186 | 14 | 0 | 386 | 14 | 0.263 | 0.608 | |
CC | TC | TT | C | T | CC | TC | TT | C | T | X2 | P | ||
TLR6 | Ma, et al. _a | 289 | 47 | 3 | 625 | 53 | 137 | 50 | 7 | 324 | 64 | 0.805 | 0.370 |
C745T | Ma, et al. _b | 61 | 88 | 31 | 210 | 150 | 38 | 46 | 26 | 122 | 98 | 2.594 | 0.107 |
(rs5743810) | Ma, et al. _c | 291 | 74 | 10 | 656 | 94 | 78 | 31 | 5 | 187 | 41 | 0.696 | 0.404 |
Salvaraj, et al. | 0 | 2 | 197 | 2 | 396 | 0 | 3 | 199 | 3 | 401 | 0.011 | 0.915 |
HWE: Hardy-Weinberg Equilibrium.