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. 2013 May 14;8(5):e63333. doi: 10.1371/journal.pone.0063333

Figure 6. Effect of HPRT-rescue on cAMP/PKA signaling.

Figure 6

Immuno-blot and densitometry quantification analysis of Syn 1and phospho-Syn I (A, B & C). Data show that the lower expression of Synapsin I protein in response to forskolin treatment in HPRT-deficient MN9D cells is abrogated in HPRT-reconstituted MN9D cells (B). p-Syn I (Ser9) expression in HPRT-reconstituted cells is partially restored (C). Error bars represent mean ± SEM of duplicate measurements of two independent experiments (n = 4). The asterisk (*) represents statistical significance (p<0.05) between forskolin treated cells control versus HPRT-deficient cells, the double asterisks (**), between forskolin-treated HPRT-deficient cells versus forskolin-treated HPRT-reconstituted cells (ANOVA and Tukey, post-hoc test).