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. 2013 May 14;8(5):e63526. doi: 10.1371/journal.pone.0063526

Table 1. Summary of the original TDT design in a 2×2 table.

Non-transmitted allele
Transmitted allele M1 M2 Total
M1 a b a+b
M2 c d c+d
Total a+c b+d 2n

The letters (a, b, c, d) represent the counts of over-transmissions of an allele from the parents to affected offsprings. The number n denotes total number of affected offsprings and 2n represents the total number of parents.