Table 1. Summary of the original TDT design in a 2×2 table.
Non-transmitted allele | |||
Transmitted allele | M1 | M2 | Total |
M1 | a | b | a+b |
M2 | c | d | c+d |
Total | a+c | b+d | 2n |
The letters (a, b, c, d) represent the counts of over-transmissions of an allele from the parents to affected offsprings. The number n denotes total number of affected offsprings and 2n represents the total number of parents.