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Recurrence-free survival analysis stratified by the (A) WHO 2004 and (B) WHO 2010 classification schemes. (A) Patients with WD endocrine carcinoma (WDCA) showed significantly inferior RFS than patients with WD endocrine tumor with benign behavior (BB) or uncertain behavior (UB; p =0.0057). (B) Using the WHO 2010 classification, grade 3 tumors (neuroendocrine carcinoma) had significantly shortened RFS than grade 1 or 2 PanNETs (p<0.0001).
