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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Neurobiol Learn Mem. 2013 Apr 6;102:34–42. doi: 10.1016/j.nlm.2013.03.007

Fig. 6.

Fig. 6

Effect of repeated administration of NaB on extinction of CPP that was acquired following conditioning by escalating dose of cocaine. Mice were conditioned by escalating doses of cocaine (3,6,12 and 24mg/kg). Two groups received saline and NaB from day 8 through 12, and an additional group received NaB from day 9 through 12 immediately following each test session. Because repeated exposure to the nonreinforced context did not cause inhibition of place preference, mice were reconditioned by saline for 4 days (days 13-16). A test on day 17 showed the loss of place preference. Reinstatement of place preference was determined by cocaine priming (11.25mg/kg) on day 18. CPP was equally reinstated in all groups. Two-way ANOVA, group (saline, NaB d8-12 and NaB d9-12) × training (context re-exposure, saline reconditioning, reinstatement) resulted in a significant group effect F[2,147]=4.97; p<0.01, a significant training effect F[6,147]=26.22; p<0.001. Bonferroni post hoc analysis showed significant difference between saline and the NaB d8-12 group (p=0.015) and between NaB d8-12 and NaB d9-12 (P=0.017); no significant difference was observed between saline and NaB d9-12 groups.