TABLE 3.
Description of reviewed published manuscripts reporting extracolonic findings for lung cancer.
| Author | Year | Country | Sample size | Age range | Mean/Median Age | Men | Number of ECFa | Number of True Positives | False Positive Rate | Prevalence (per 1000) | PPV |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Screening populations | |||||||||||
| Ginnerup Pederson B [33] | 2003 | Denmark | 75 | 33–78 | 61 | 53.3 | 1 | 1 | 0 | 1.3 | 100.0 |
| Gluecker TM [21] | 2003 | US | 681 | 41–80 | 64 | 62.6 | 26 | 1 | 3.7 | 0.1 | 3.8 |
| Chin M [23] | 2005 | Australia | 432 | 50–69 | - | 53.2 | 3 | 0 | 0.7 | 0 | 0 |
| Kimberly JR [34] | 2008 | US | 143 | 44–83 | 57 | 48 | 23 | NA | - | - | - |
| Pickhardt PJ [35] | 2010 | US | 10,286 | - | 59.8 | 52.3 | NA | 8 | - | 0.1 | - |
| Veerappan GRb [18] | 2010 | US | 2277 | - | 59 | 56 | 5 | 1 | 0.2 | 0.0 | 20.0 |
| Non-screening populations | |||||||||||
| Rajapaksa RC [38] | 2004 | US | 250 | - | 62.5 | 98 | 3 | NA | - | - | - |
| Spreng A [22] | 2005 | Switzerland | 102 | 20–91 | 66 | 61.7 | NA | 1 | - | 1.0 | - |
| Yee J [39] | 2005 | US | 500 | 30–90 | 62.5 | 100 | 7 | 0 | 1.4 | 0.0 | 0.0 |
| Tolan D [28] | 2007 | UK | 400 | 70–96 | 79.6 | 37.5 | 7 | 6 | 0.3 | 1.5 | 85.7 |
| Roberts-Thomson IC [25] | 2008 | Australia | 225 | 25–85 | 60 | 51.0 | 2 | NA | - | - | - |
| White TJ [40] | 2009 | US | 150 | 40–83 | 60.9 | 48.7 | NA | 1 | - | 0.7 | - |
| Unknown/Mixed | |||||||||||
| Hara AK [41] | 2000 | US | 264 | 33–88 | 64 | 55.3 | 8 | 0 | 3.0 | 0.0 | 0 |
| Iafrate F [42] | 2008 | Italy | 136 | 70–92 | 81 | NA | 1 | NA | - | - | - |
| Park SK [43] | 2009 | South Korea | 920 | 34–87 | 57.3 | 58.1 | 9 | NA | - | - | - |
a
ECF=extracolonic finding, PPV=positive predictive value, NA=not available, (-)=could not calculate
b
Only includes carcinoma detected from the E4 findings, even though additional cancer was detected among persons with E3 findings. The total number of E3 findings could not be determined.