Table 2. miRNAs signifcantly altered by age alone in the rat female hippocampus.

Female Fisher 344 rats at 3 and 18 mo. old were ovariectomized. Brains were removed 7 days post-ovariectomy, hippocampus microdissected, total RNA isolated, and processed for mature miRNA expression using a rat microRNA microarray platform (Sanger 18.0 miRBase probes, LC Sciences).

miRNA	p-value
miR-218a*	1.95E-03
miR-495*	3.23E-03
miR-26a*	3.26E-03
miR-423-3p	2.08E-02
miR-382	2.12E-02
miR-376b-3p	2.88E-02
miR-379	2.95E-02
let-7d-3p	3.03E-02
miR-125b-5p*	3.46E-02
miR-137	3.97E-02
miR-539	4.15E-02
miR-7a*	5.92E-02
miR-21	5.82E-03
miR-219-2-3p	7.52E-03
miR-150	1.87E-02
miR-329	2.56E-02
miR-181b*	4.04E-02
miR-29a*	4.28E-02
miR-323	5.08E-02
miR-34c	6.25E-02
miR-132	6.92E-02

An * indicates miRNAs that were also significantly altered by E₂ treatment.