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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Free Radic Biol Med. 2013 Feb 14;60:10.1016/j.freeradbiomed.2013.02.003. doi: 10.1016/j.freeradbiomed.2013.02.003

Figure 6. ATN-224 enhances paraquat and chemotherapeutic drug-induced cell death.

Figure 6

A. Caspase 3 activity measured in WEHI7.2 (24 h), Hb12 (18 h) and 200R (30 h) cells treated with vehicle, ATN-224, 50 μM paraquat (PQ) or a combination of ATN-224 and paraquat. B. Cell viability in WEHI7.2 and WEHI7.2 variant cells treated with vehicle, ATN-224 (3 nM WEHI7.2; 4.5 nM Hb12 and 200R), doxorubicin (5 nM and 10 nM WEHI7.2 and 200R; 10 nM and 20 nM Hb12) or a combination of ATN-224 and doxorubicin. All values are mean + SEM (n ≥). *, significantly different from vehicle treated control cells (p ≤ 0.05). **, significantly different from ATN-224 treated cells (p ≤ 0.05).