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The number of fibroblasts in baboon skin biopsies displaying elevated levels of the heterochromatin protein HIRA increases with age of the animal. (A) Immunostaining of dermal fibroblasts of a young (5 year, top row) and an old (29 year, bottom row) animal with an antibody against HIRA (green). Nuclear DNA was counterstained with DAPI (blue). (B) Quantitation of HIRA positive fibroblasts in skin biopsies of baboons at indicated ages.
