Table 2.
Comparison of the clinical and hormonal features of CD patients carrying the BclI and wild-type alleles.
| Features | Wild Type (n = 22) | BclI carriers (n = 42) | p-value |
| Age at diagnosis, years | 32.2±10.8 | 31.5±12.5 | 0.773 |
| Disease duration, years | 3.6±3.7 | 4.5±3.8 | 0.185 |
| BMI, kg/m2 | 29.6±4.7 | 34.4±7 | 0.012 |
| Weight gain, kg | 20.2±10.1 | 25±16.7 | 0.445 |
| Systolic blood pressure, mmHg | 135.3±15.2 | 142.5±22 | 0.256 |
| Diastolic blood pressure, mmHg | 90±10.9 | 91.9±15.4 | 0.815 |
| Fasting glucose, mg/dL | 119±49.3 | 98.7±35.2 | 0.086 |
| Morning serum cortisol, μg/dl | 26.3±16.7 | 26.1±16.7 | 0.845 |
| Basal ACTH, μg/dl | 93.7±83.7 | 73.3±64 | 0.315 |
| F after 1 mg DST, μg/dL | 15.2±14.2 | 15.4±11.2 | 0.963 |
| F after 8 mg DST, μg/dL | 9±7.6 | 10.2±9.3 | 0.915 |
| UFC, μg/24 h | 1,338±1,143 | 1,011±506 | 0.683 |
| Image | |||
| Microadenoma, n° (%) | 17 (77.3) | 30 (71.5) | 0.837 |
| Macroadenoma, n° (%) | 3 (13.6) | 8 (19) | 0.844 |
| Not identified, n° (%) | 2 (9.1) | 4 (9.5) | 0.692 |
Values are reported as the means±SD. BMI, Body mass index; DST, Dexamethasone suppression test, DST; Urine free cortisol, UFC; F, Cortisol.