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. 2013 Apr 11;2013:906590. doi: 10.1155/2013/906590

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Copyright © 2013 Gabriela da Silva Xavier et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Electron Micrographs and Optical Projection Tomography (OPT) in ZnT8^+/+ and ZnT8^−/− mice. (a) Transmission electron microscopy images of isolated islets from ZnT8^+/+ and ZnT8^−/− male mice at high magnification (scale bar 1 mm) reveals the appearance of rod-shaped core granules in ZnT8^−/− cells, indicated by red arrows (n = 3 mice). Sections were cut and images were acquired by Dr. Raffaella Carzaniga and Ms. Katrin Kronenberger. (b) Representative three-dimensional OPT projections of whole fixed and permeabilised pancreas from ZnT8^−/− and ZnT8^+/+ mice. In red are the insulin positive structures (β cells). The overall shape of the whole pancreas was visualized as autofluorescence and is apparent as white/grey shading. Scale bar = 1 cm. (c) Relative (right panel) and absolute (left panel) β-cell volume (n = 2 pancreata per genotype).