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. Author manuscript; available in PMC: 2013 Sep 5.
Published in final edited form as: Sci Transl Med. 2012 Sep 5;4(150):150ra122. doi: 10.1126/scitranslmed.3004291

Figure 1.

Figure 1

Chronological changes in sleep-wake patterns and diurnal fluctuations of interstitial fluid (ISF) amyloid beta (Aβ) in APPswe/PS1δE9 mice. (A–C, G–I) Diurnal changes of ISF Aβ1-x in APPswe/PS1δE9 mice at 3, 6, 9 months across 2 days shown as % average of 2 days of absolute values of ISF Aβ1-x in the hippocampus (A–C) and striatum (G–I). (D–F, J–L) Comparison of % average of 2 days of ISF Aβ1-x between dark and light periods in the hippocampus (D–F) and striatum (J–L) of each age group (n = 6–8 per group; two tailed t-test). (M, N) Absolute levels of ISF Aβ1-x in the hippocampus (M) and striatum (N) of 3, 6, and 9 month old APPswe/PS1δE9 mice (n = 6–8 per group; one-way ANOVA, followed by Tukey’s post hoc test). *P < 0.05; **P <0.01; ***P< 0.001. Values represent mean ± s.e.m.