Comparison of transduction efficiencies of AAV2/2 and pseudotyped vectors AAV2/5, AAV2/7 and AAV2/8 in wounds. In the cells of the epidermis, both AAV2/5 and AAV2/8 resulted in significantly increased transduction efficiencies compared to AAV2/2 (A). Similarly, in the cells of the dermis, AAV2/5 and AAV2/8 resulted in higher gene transfer than AAV2/2 (B). In the skeletal muscle layer panniculus carnosus, AAV2/7 and AAV2/8 resulted in more muscles fascicles transduced than AAV2/2 (C). High powered fields (HPF- 40x magnification images) (* p<0.05, ** p<0.001, *** p<0.0001).