Skip to main content
. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Wound Repair Regen. 2012 Jun 19;20(4):592–600. doi: 10.1111/j.1524-475X.2012.00810.x

Figure 4.

Figure 4

Comparison of transduction efficiencies of AAV2/2 and pseudotyped vectors AAV2/5, AAV2/7 and AAV2/8 in in vitro cultures of murine and human fibroblasts at day 3 and day 7 post vector administration. In murine fibroblasts at day 3 post transduction, AAV2/5 had maximal gene transfer (A). In human fibroblasts, AAV2/5 and AAV2/8 had higher transduction efficiencies (B). At 7 days after AAV administration, the percentage of transduced cells in all the vector preparations increased significantly compared to day 3. AAV2/5 continued to demonstrate higher transduction efficiency in murine cells (4C). In human fibroblasts, both AAV2/2 and AAV2/8 show higher gene transfer rates (4D). High powered fields (HPF- 20x magnification images) (* p<0.05, ** p<0.001, *** p<0.0001).