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. Author manuscript; available in PMC: 2013 May 15.
Published in final edited form as: Curr Opin Genet Dev. 2012 Oct 11;22(5):450–458. doi: 10.1016/j.gde.2012.09.002

Figure 3. Interspecific cybrid reprogramming systems.

Figure 3

(i) Nuclei from one species are incubated into M-phase egg extracts prepared from another species, resulting in nuclear and spindle scaling. (ii) In interspecific cytoplast fusion, cultured cells from one species are enucleated and fused with cells from another species. This can be combined with mtDNA-depletion of the other species cells to generate xenomitochondrial cybrid cells. (iii) Cybrid embryos can be generated either by cross-fertilization, iICSI or iNT using enucleated interspecies oocyte.