Table 4.
CAMP
|
LODO
|
Asthma Trial
|
||||
---|---|---|---|---|---|---|
Estimate | P value | Estimate | P value | Estimate | P value | |
Clinical Predictive Test | ||||||
FEV1 | − 0.63 | 0.02 | − 0.23 | 0.27 | − 0.11 | 0.65 |
Pharmacogenetic Predictive Test | ||||||
rs10956264 | − 0.14 | 0.78 | 1.31 | 0.038 | − 0.16 | 0.71 |
rs1348482 | 0.32 | 0.041 | 5.18 | 0.96 | − 4.68 | 0.96 |
rs2831845 | − 6.75 | 0.97 | 0.12 | 0.62 | 0.28 | 0.13 |
rs17772026 | − 0.11 | 0.43 | 0.13 | 0.45 | − 0.12 | 0.34 |
rs7841870 | 0.43 | 0.38 | − 6.44 | 0.96 | 4.85 | 0.96 |
rs2223098 | 0.0089 | 0.95 | − 0.026 | 0.90 | 0.038 | 0.77 |
rs7155790 | 0.12 | 0.55 | − 0.089 | 0.72 | 0.081 | 0.65 |
rs12511017 | − 0.15 | 0.26 | − 0.22 | 0.21 | − 0.053 | 0.66 |
Combined Clinical and Pharmacogenetic Predictive Test | ||||||
FEV1 | − 0.60 | 0.033 | − 0.38 | 0.14 | − 0.23 | 0.36 |
rs10956264 | 0.18 | 0.75 | 1.47 | 0.029 | − 0.16 | 0.70 |
rs1348482 | 0.29 | 0.065 | 5.16 | 0.97 | − 4.79 | 0.96 |
rs2831845 | − 6.75 | 0.97 | 0.09 | 0.73 | 0.28 | 0.12 |
rs17772026 | − 0.11 | 0.44 | − 0.018 | 0.93 | − 0.12 | 0.33 |
rs7841870 | 0.10 | 0.86 | − 6.58 | 0.96 | 4.96 | 0.96 |
rs2223098 | −0.0050 | 0.97 | 0.0044 | 0.98 | 0.033 | 0.80 |
rs7155790 | 0.13 | 0.52 | − 0.21 | 0.44 | 0.075 | 0.68 |
rs12511017 | − 0.12 | 0.36 | − 0.23 | 0.25 | − 0.051 | 0.68 |
CAMP, Childhood Asthma Management Program; FEV1, forced expiratory volume in 1 s; LODO, Effectiveness of Low Dose Theophylline as Add-on Treatment in Asthma Trial.