Table 1. β₁AR Binding Affinities, LE, LLE, and cLogP Values of 8–24.

compd	R, R1, R2	β1AR pKi a	LE	cLogP b	LLE
8	R1, R2 = H	5.20	0.44	1.59	3.61
9	R = H	5.87	0.67	1.11	4.76
10		5.63	0.48	1.51	4.12
11		5.60	0.48	1.46	4.14
12	R = 3-Cl, 5-Cl	7.07	0.69	3.03	4.04
13	R = 2-Cl, 3-Cl	6.97	0.68	2.90	4.07
14	R = 3-Cl, 4-Cl	6.67	0.65	2.67	4.00
15	R = 3-Me, 4-Me	6.13	0.60	2.03	4.10
16	R = 2-Me, 3-Me	6.27	0.61	2.03	4.24
17	R = 3-CF3, 5-CF3	5.90	0.40	4.03	1.87
18	R = 3-OMe, 5-OMe	5.80	0.49	0.79	5.01
19		7.17	0.65	1.03	6.14
20	R1 = Me, R2 = H	6.65	0.53	2.05	4.60
21	R1 = H, R2 = 2-thienyl	6.60	0.43	2.39	4.21
22		5.80	0.47	1.44	4.36
23		6.70	0.43	3.69	3.01
24		6.17	0.40	3.06	3.11

^aSee Experimental Section for assay conditions; pK_i = −log₁₀ K_i.

^bReference (56).