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In vivo evaluation of 22 in mice on glucose tolerance. (A) Effect of 22 on acute IPGTT in normal mice. Mice were dosed ip with 22, vehicle, or control (sitagliptin, 10 mg/kg). (B) Effect of 22 on OGTT in a chronic study in DIO mice: acute (4 weeks vehicle prior to treatment with 22), chronic (4 weeks treatment with 22), and control (vehicle). Means ± standard errors (n = 6) are shown (*, p < 0.05; **, p < 0.01; ***, p < 0.001).
