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. 2012 Dec 7;15(5):417–426. doi: 10.1111/dom.12040

Figure 4.

Figure 4

Plasma exenatide exposure in ZDF rats dosed subcutaneously twice daily at 6, 40 and 250 µg/kg/day or with vehicle for 3 months. (A) Peak plasma exenatide concentrations (Cmax) and (B) calculated AUC[0–∞]. Dotted horizontal lines represent mean values observed in patients with type 2 diabetes mellitus treated with the standard exenatide regimen: Cmax = 0.211 ng/ml and AUC[0–∞] = 1.036 ng/h/ml.