Table 2.

Incidence and severity of histological changes in pancreas

	Exenatide dose (µg/kg/day)
Parameter	0 (n = 16)	6 (n = 15)	40 (n = 15)	250 (n = 15)	0 (n = 7)	6 (n = 8)	40 (n = 8)	250 (n = 8)
Treatment phase	Main				Recovery
Islet hypertrophy (total)	0	7	12	13	0	5	7	7
Minimal	0	6	11	10	0	4	5	7
Slight	0	1	1	2	0	1	2	0
Moderate	0	0	0	1	0	0	0	0
Hyperplasia acinar cell: focal (total)	1	1	2	1	0	0	2	1
Minimal	0	1	1	1	0	0	1	1
Slight	1	0	1	0	0	0	1	0
Acinar cell regeneration (total)	0	0	0	0	0	1	0	0
Slight	0	0	0	0	0	1	0	0
Acinar cell necrosis (total)	0	0	0	0	1	0	0	0
Slight	0	0	0	0	1	0	0	0
Duct intraluminal concretion (total)	2	3	4	5	0	2	1	0
Minimal	1	2	4	4	0	1	1	0
Slight	0	1	0	1	0	1	0	0
Moderate	1	0	0	0	0	0	0	0
Subacute inflammation (total)	0	0	0	1	0	0	1	0
Slight	0	0	0	1	0	0	1	0
Acute inflammation (total)	3	1	0	0	1	0	0	1
Minimal	1	1	0	0	1	0	0	1
Slight	1	0	0	0	0	0	0	0
Moderate	1	0	0	0	0	0	0	0
Vascular/perivascular inflammation (total)	0	0	0	0	1	0	0	0
Slight	0	0	0	0	1	0	0	0
Haemorrhage (total)	0	0	0	0	1	0	0	0
Slight	0	0	0	0	1	0	0	0