Table 1. Frequency of perforin mutations in melanoma patients.
| Tumor group | Samples, n | A91V, n | Other variants, n | A91V variant, % | Variant (total), % | Fisher’s Test |
|---|---|---|---|---|---|---|
| Control |
118 |
9 |
0 |
7.6 |
7.6 |
N/A |
| Melanoma |
143 |
14 |
2* |
9.8 |
11.2 |
p = 0.40 |
| Melanoma + lymphoma |
15 |
2 |
2 |
13.3 |
26.7 |
p = 0.04 |
| Melanoma + other | 28 | 3 | 0* | 10.7 | 10.7 | p = 0.71 |
*
The N252S polymorphism, which has no apparent effect on perforin function in vitro, was found in a third patient but s/he was not included in the statistical calculations.