Figure 5.

AB103-treated mice exhibit fewer inflammatory cells than infected, untreated mice. Upper panels, Muscle section of a mouse 48 hours after Streptococcus pyogenes (GAS) infection. GAS-infected mice developed severe, acute inflammatory infiltrates primarily in the fascia (upper left panel). This was significantly reduced in mice treated with AB103 (5 mg/kg) and among muscle fibers (upper right panel). Lower panels, Muscle section of mice 72 hours after GAS infection. Apart from inflammatory infiltrates, necrosis of muscle cells was observed in GAS-infected, untreated mice (lower left panel). Necrosis was strongly attenuated in AB103-treated mice (lower right panel).