Table 3.
Frequency of plaque pathology scores for ApoE ϵ4 carriers and non-carriers by age group
| Age group | ≤69 | 70 - 79 | 80 - 89 | ≥90 | |||||
|---|---|---|---|---|---|---|---|---|---|
| |
|
ϵ4+ |
ϵ4 - |
ϵ4+ |
ϵ4 - |
ϵ4+ |
ϵ4 - |
ϵ4+ |
ϵ4 - |
| Frontal Plaque Density |
None |
0 (0%) |
0 (0%) |
0 (0%) |
0 (0%) |
0 (0%) |
0 (0%) |
0 (0%) |
1 (1%) |
| Sparse |
0 (0%) |
0 (0%) |
1 (0.7%) |
1 (0.7%) |
0 (0%) |
3 (1.1%) |
0 (0%) |
1 (1%) |
|
| Moderate |
2 (5.1%) |
1 (2.6%) |
5 (3.6%) |
8 (5.8%) |
5 (1.8%) |
13 (4.6%) |
2 (2%) |
11 (10.8%) |
|
| Frequent |
21 (58.9%) |
15 (38.5%) |
86 (61.87%) |
38 (27.3%) |
147 (52.5%) |
112 (40%) |
38 (37.3%) |
49 (48%) |
|
| |
|
p = 0.78 |
p = 0.03 |
p = 0.003 |
p = 0.03 |
||||
| Temporal Plaque Density |
None |
0 (0%) |
0 (0%) |
0 (0%) |
0 (0%) |
0 (0%) |
0 (0%) |
0 (0%) |
0 (0%) |
| Sparse |
0 (0%) |
0 (0%) |
0 (0%) |
2 (1.4%) |
0 (0%) |
3 (1.1%) |
0 (0%) |
2 (2%) |
|
| Moderate |
1 (2.6%) |
0 (0%) |
7 (5.0%) |
6 (4.3%) |
7 (2.5%) |
21 (7.5%) |
2 (2%) |
8 (7.9%) |
|
| Frequent |
22 (56.4%) |
16 (41.0%) |
85 (61.2%) |
39 (28.1%) |
146 (52.1%) |
103 (36.8%) |
38 (37.6%) |
51 (50.5%) |
|
| |
|
p = 0.40 |
p = 0.08 |
p < 0.001 |
p = 0.08 |
||||
| Parietal Plaque Density |
None |
0 (0%) |
0 (0%) |
0 (0%) |
0 (0%) |
0 (0%) |
0 (0%) |
0 (0%) |
2 (2%) |
| Sparse |
0 (0%) |
0 (0%) |
0 (0%) |
1 (0.7%) |
0 (0%) |
1 (0.4%) |
0 (0%) |
1 (1%) |
|
| Moderate |
0 (0%) |
0 (0%) |
5 (3.6%) |
6 (4.4%) |
3 (1.1%) |
14 (5%) |
1 (1%) |
7 (7%) |
|
| Frequent |
23 (59%) |
16 (41%) |
87 (63%) |
39 (28.3%) |
148 (53.1%) |
113 (40.5%) |
39 (39%) |
50 (50%) |
|
| |
|
p = 0.99 |
p = 0.05 |
p = 0.001 |
p = 0.03 |
||||
| Hippocampal Plaque Density |
None |
0 (0%) |
0 (0%) |
2 (1.5%) |
7 (5.1%) |
3 (1.1%) |
11 (3.9%) |
0 (0%) |
8 (8%) |
| Sparse |
3 (7.7%) |
1 (2.6%) |
5 (3.6%) |
6 (4.4%) |
18 (6.4%) |
38 (13.6%) |
9 (9%) |
15 (15%) |
|
| Moderate |
4 (10.3%) |
6 (15.4%) |
44 (31.9%) |
18 (13%) |
70 (25%) |
41 (14.6%) |
15 (15%) |
23 (23%) |
|
| Frequent |
16 (41%) |
9 (23.1%) |
40 (29%) |
16 (11.6%) |
62 (22.1%) |
37 (13.2%) |
16 (16%) |
14 (14%) |
|
| |
|
p = 0.56 |
p = 0.03 |
p < 0.001 |
p = 0.02 |
||||
| Entorhinal Plaque Density |
None |
0 (0%) |
0 (0%) |
1 (0.7%) |
4 (2.9%) |
2 (0.7%) |
2 (0.7%) |
1 (1%) |
3 (3%) |
| Sparse |
0 (0%) |
0 (0%) |
1 (0.7%) |
5 (3.6%) |
3 (1.1%) |
13 (4.6%) |
1 (1%) |
1 (1%) |
|
| Moderate |
2 (5.1%) |
2 (5.1%) |
22 (15.8%) |
14 (10.1%) |
38 (13.6%) |
39 (13.9%) |
9 (8.9%) |
24 (23.8%) |
|
| Frequent |
21 (53.9%) |
14 (35.9%) |
68 (48.9%) |
24 (17.3%) |
110 (39.3%) |
73 (26.1%) |
29 (28.7%) |
33 (32.7%) |
|
| p = 0.70 | p = 0.002 | p = 0.005 | p = 0.08 | ||||||
n (% = percent).