Table 3.

Pathway analysis of cDNA arrays

Drug	SVM Pathways	MNI Pathways	Known MoA
Terbinafine	Ergosterol biosynthetic process (27)	Steroid metabolism (2130)	Inhibition of squalene monooxygenase, thus blocking the biosynthesis of ergosterol
Lovastatin	-	Lipid metabolism (16244)	Inhibition of HMG-CoA reductase
Itraconazole	Ergosterol biosynthetic process (256)	Steroid metabolism (2130)	Interaction with 14-α demethylase an enzyme necessary to convert lanosterol to ergosterol.
Hydroxyurea	Deoxyribonucleotide biosynthetic process (704)	Dna replication (5480)	Inhibition of ribonucleotide reductase and consequently of DNA synthesis
Tunicamycin	Cellular nitrogen compound catabolic process (6678), Protein targeting to ER (585)	Protein-ER targeting (585)	N-linked glycosylation