Table 3.
Age-associated changes in the levels of mouse circulating 5′ tRNA halves and the effects of CR on the age-associated changes
| Age | CR | ||||||
|---|---|---|---|---|---|---|---|
|
tRNA* |
Young control † |
Old control† |
Old CR† |
FC‡ |
p-value |
FC‡ |
p-value |
|
His-GTG |
|
||||||
| chr4:82619623-82619694 |
797 |
2988 |
1554 |
3.8 |
3.1E-11 |
−2 |
6.8E-04 |
| chr2:122377363-122377434 |
798 |
2994 |
1549 |
3.8 |
3.7E-11 |
−2 |
6.4E-04 |
| chr3:96452495-96452566 |
307 |
1140 |
590 |
3.8 |
3.8E-11 |
−2 |
6.1E-04 |
| chr2:122375494-122375565 |
808 |
2990 |
1533 |
3.8 |
3.9E-11 |
−2 |
5.0E-04 |
| chr2:122377968-122378039 |
309 |
1163 |
600 |
3.8 |
4.2E-11 |
−2 |
6.6E-04 |
| chr3:96458070-96458141 |
802 |
2993 |
1523 |
3.8 |
4.3E-11 |
−2 |
4.8E-04 |
| chr3:96500366-96500437 |
796 |
2954 |
1524 |
3.8 |
4.5E-11 |
−2 |
5.9E-04 |
| chr3:96410069-96410140 |
301 |
1148 |
590 |
3.9 |
2.0E-11 |
−2 |
5.5E-04 |
|
Arg-CCG |
|
||||||
| chr11:107012866-107012938 |
1243 |
256 |
302 |
−5 |
9.9E-12 |
1.2 |
4.7E-01 |
|
Cys-GCA |
|
||||||
| chr11:97798906-97798977 |
933 |
370 |
688 |
−2.6 |
2.5E-06 |
1.8 |
2.4E-03 |
| chr11:97988246-97988317 |
928 |
376 |
700 |
−2.5 |
3.9E-06 |
1.8 |
2.2E-03 |
| chr11:97988923-97988994 |
930 |
360 |
684 |
−2.6 |
1.3E-06 |
1.9 |
1.5E-03 |
|
Gly-GCC |
|
||||||
| chr1:171074302-171074372 |
16868 |
3739 |
3807 |
−4.5 |
3.5E-14 |
−1 |
9.6E-01 |
| chr1:171066631-171066701 |
16820 |
3730 |
3790 |
−4.5 |
4.3E-14 |
−1 |
9.6E-01 |
| chr1:171081876-171081946 |
16779 |
3725 |
3788 |
−4.4 |
5.3E-14 |
−1 |
9.6E-01 |
|
Lys-CTT |
|
||||||
| chr17:23533962-23534034 |
4175 |
1939 |
3286 |
−2.2 |
8.8E-06 |
1.7 |
3.7E-03 |
| chr3:96428235-96428307 |
4215 |
1964 |
3353 |
−2.2 |
1.0E-05 |
1.7 |
3.3E-03 |
| chr17:23547360-23547432 |
4098 |
1923 |
3272 |
−2.2 |
1.1E-05 |
1.7 |
3.4E-03 |
| chr17:23535332-23535404 |
14085 |
6569 |
11132 |
−2.2 |
1.2E-05 |
1.7 |
4.1E-03 |
| chr13:23436340-23436412 |
4181 |
1962 |
3321 |
−2.2 |
1.2E-05 |
1.7 |
3.9E-03 |
| chr3:96499512-96499584 |
13865 |
6507 |
11017 |
−2.2 |
1.3E-05 |
1.7 |
3.9E-03 |
| chr11:48833883-48833955 |
13905 |
6539 |
11051 |
−2.2 |
1.4E-05 |
1.7 |
4.1E-03 |
|
Val-AAC |
|
||||||
| chr13:23401073-23401145 |
1247 |
451 |
814 |
−2.8 |
3.3E-07 |
1.8 |
4.1E-03 |
| chr13:23413248-23413320 | 1246 | 467 | 836 | −2.7 | 5.4E-07 | 1.8 | 4.0E-03 |
*tRNA isoacceptor identity with corresponding genomic positions of the tRNA genes in the mouse mm10 genome.
†Average tRNA read count for the indicated experimental group reported as counts per million (cpm) reads in the sequenced library from the indicated experimental group.
‡Fold change calculated by EdgeR from pairwise comparisons between the young and old control groups for the age effect, or between the old control and old CR groups for the CR effect.