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a. Docking of the best compound, NM372, on the complex composed of GCP4 (WT) and γ-tubulin, without compound (above) and with compound (below). b. Docking of the best compound, NM372, on the complex composed of GCP4 (S623R) and γ-tubulin, without compound (above) and with compound (below). This figure clearly illustrates how the bulky and positively charged arginine side chain blocks the binding pocket.
