Figure 3. Effects of nuciferine on liver histology.

(A) Liver sections from hamsters fed the normal diet showed normal liver histology. (B) In HFD fed hamsters, numerous macrovesicular fat droplets (arrow head) and mild necroinflammatory foci (arrows) were present. (C) and (D) Treatment with nuciferine (10 and 15 mg/kg·BW/day) for 8 weeks resulted in prevention of hepatic fatty deposition in hepatocytes and infiltration of the inflammatory cells in the hepatic parenchyma. The tissues were surgically excised and subjected to histological study by staining with hematoxylin and eosin. All the magnification is 200×.