Table 3. Effects of nuciferine on serum biochemical parameters in high-fat-fed hamsters.
| ND | HFD | NFNL | NFNH | |
| Inflammation | ||||
| TNF-α (pg/ml) | 169.1±12.3a | 236.1±28.3b | 210.5±26.1b | 166.2±11.4a |
| IL-6 (pg/ml) | 466±77.6a | 657.6±55.4b | 613.2±81.4b | 481.1±56.9a |
| Oxidative stress | ||||
| SOD (U/ml) | 54.9±8.7a | 40.9±3.6b | 46.5±7.00b | 60.6±9.7a |
| CAT (U/ml) | 3.70±0.47a | 1.52±0.20b | 2.82±0.52c | 4.38±0.77a |
| GPx | 748.5±68.2a | 649.6±81.1b | 690.5±60.6ab | 840.6±95.3c |
| MDA (nmol/l) | 4.22±0.54a | 6.59±0.79b | 5.81±0.70c | 5.49±0.71c |
| Insulin resistance | ||||
| Adiponectin (pg/ml) | 120.3±21.4a | 86.7±6.8b | 91.2±7.3b | 109.8±9.7a |
| Leptin (pg/ml) | 313.4±25.9a | 416.7±32.4b | 387.6±40.2c | 345.1±19.1d |
| Insulin (ng/ml) | 0.76±0.08a | 1.41±0.10b | 1.36±0.10b | 1.05±0.14c |
| Glucose (mg/dl) | 86.35±13.98 | 86.94±14.10 | 89.32±9.41 | 85.00±13.05 |
| HOMA-IR | 2.92±0.56a | 5.41±0.68b | 5.39±0.63b | 3.96±0.78c |
| Others | ||||
| β-HBA (µmol/l) | 1141.7±149.3a | 895.7±123.1b | 1150.0±202.8a | 1547.0±214.3c |
| Uric acid (µmol/l) | 70.3±12.7 | 67.3±17.4 | 73.4±11.4 | 70.8±12.0 |
Values are means±SD, n = 10 hamsters in each group. ND: normal diet group, HFD: high-fat diet group, HFNL: low dosage nuciferine group (HFD+10 mg/kg·BW/day), HFNH: high dosage nuciferine group (HFD+15 mg/kg·BW/day). a, b, c, d: Means in the same row with different online letters differ significantly, p<0.05.