Table 4. Effects of nuciferine on hepatic mRNA expression involved in lipid metabolism.

	ND	HFD	NFNL	NFNH
Lipogenesis
SREBP-1c	1.00±0.08a	2.72±0.33b	2.25±0.19b	1.55±0.25c
LXR-α	1.00±0.07a	3.22±0.34b	2.39±0.37c	1.71±0.25d
ACC	1.00±0.11a	1.73±0.08b	1.43±0.15c	1.32±0.05c
FAS	1.00±0.13a	2.57±0.28b	2.04±0.24b	1.44±0.07c
SCD-1	1.00±0.08a	1.91±0.32b	1.35±0.18c	1.32±0.23c
DGAT-2	1.00±0.06a	3.45±0.69b	3.52±0.39b	3.65±0.42b
FFA β-oxidation
PPAR-α	1.00±0.08a	0.66±0.04b	0.93±0.05a	1.24±0.13c
CPT-1	1.00±0.10a	0.73±0.05b	1.24±0.09c	1.40±0.09c
ACO	1.00±0.06	1.15±0.13	1.02±0.08	0.97±0.09
FFA infiltration and VLDL secretion
PPAR-γ	1.00±0.10a	3.15±0.32b	2.63±0.19bc	2.30±0.33c
LPL	1.00±0.09a	6.98±0.90b	3.68±0.32c	2.70±0.45d
CD36	1.00±0.05a	3.62±0.27b	2.13±0.26c	1.55±0.13d
ApoB	1.00±0.14a	0.49±0.03b	0.86±0.06ac	1.26±0.16d
MTP	1.00±0.10a	0.39±0.05b	0.42±0.07b	0.86±0.12a
Inflammation and Oxidation stress
TNF-α	1.00±0.08a	4.12±0.87b	3.05±0.52c	2.85±0.36c
CYP2E1	1.00±0.12a	2.69±0.16b	2.45±0.37b	1.53±0.06c

Specific mRNA values were normalized to the expression of 18S rRNA as described in Materials and Methods. Values are expressed as the means±SD (n = 4∼6) relative to the values obtained in hamsters fed the normal diet at 8 weeks, which were arbitrarily assigned a value of 1.00. ND: normal diet group, HFD: high-fat diet group, HFNL: low dosage nuciferine group (HFD+10 mg/kg·BW/day), HFNH: high dosage nuciferine group (HFD+15 mg/kg·BW/day). a, b, c, d: Means in the same row with different online letters differ significantly, p<0.05.