Table 3.
Patient characteristics - knee
|
Study, Year |
Number of patients TXA/C |
Gender distribution % male TXA /C |
Mean age TXA,C (SD or range) |
Mean weight (kg) - TXA, C (SD or Range) |
TBL - TXA,C (mL) (SD) |
P Value |
Number of patients requiring allogeneic transfusions (TXA, C) |
P Value |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TXA | C | TXA | X | TXA | C | TXA | X | TCA | C | TXA | C | |||
|
Hiippala, 1995[27] |
15 |
13 |
13 |
23 |
70 (56–82) |
70 (63–78) |
72 (10) |
74 (10) |
847 (356) |
1549 (574) |
<0.001 |
10 |
12 |
N/R |
|
Benoni, 1996[17] |
43 |
43 |
30 |
23 |
76 (7) |
74 (7) |
73 (14) |
78 (16) |
730 (280) |
1410 (480) |
<0.001 |
8 |
24 |
<0.001 |
|
Hiippala, 1997[12] |
39 |
38 |
10 |
21 |
70 (7) |
69 (5) |
74 (13) |
78 (12) |
689 (289) |
1509 (643) |
< 0.0001 |
17 |
34 |
<0.0001 |
|
Jansen, 1999[2] |
21 |
21 |
24 |
14 |
70.7 (62–80) |
71.0 (64–84) |
78.8 (11.0) |
75.8 (12.4) |
678 (352) |
1419 (607) |
<0.001 |
2 |
13 |
<0.001 |
|
Engel, 2001[42] |
12 |
12 |
50 |
50 |
71 (9) |
66 (11) |
83 (12) |
80 (13) |
800 (295–1050) |
865 (245–1370) |
N/R |
0 |
3 |
N/R |
|
Ellis, 2001[36] |
10 |
10 |
40 |
30 |
71 (5) |
72 (8) |
80 (12) |
77 (15) |
N/R |
N/R |
N/R |
1 |
7 |
N/R |
|
Tanaka, 2001[41]** |
73 |
26 |
29, 32, 30 |
|
65 (59–70), , 65 (60–71), 65 (59–69) |
65 (58–70) |
60 (45–70), 60 (45–70), 60 (40–76) |
61 (45 to 76) |
720.4* (187.2) |
1470 (264.8) |
N/R |
17, 16, 14 |
26 |
N/R |
|
Veien, 2002[3] |
15 |
15 |
73 |
93 |
70.5 (9.5) |
69.5 (9.0) |
78.7 (12.3) |
74.3 (14.1) |
409.7 (174.9) |
761.7 (313.1) |
<0.001 |
0 |
2 |
N/R |
|
Good, 2003[18] |
27 |
24 |
33 |
25 |
72 (46–83) |
72 (50–84) |
79 (13) |
80 (13) |
1045◊ (368.7 ) |
1426◊ (620.9 ) |
<0.001 |
3 |
14 |
<0.001 |
|
Zohar, 2004[35]*** |
60 |
20 |
30, 20, 40 |
35 |
73 (8), 69 (7), 69 (10) |
73 (7) |
78 (12), 75 (13), 77 (13) |
75 (12) |
N/R |
N/R |
N/R |
3, 2, 4 |
12 |
N/R |
|
Orpen, 2006[5] |
15 |
14 |
47 |
79 |
73 (95% CI 70–78) |
69 (95% CI 63–74) |
83 (95% CI 69–112) |
77 (95% CI 58–96) |
660 (317.6)† |
726 (333.0) † |
0.55 |
1 |
3 |
N/R |
|
Camarasa, 2006[31] |
35 |
60 |
26 |
20 |
73 (61–84) |
72 (52–85) |
N/R |
1095 (473) |
1784 (660) |
N/R |
N/R |
N/R |
||
|
Álvarez, 2007[6] |
46 |
49 |
15 |
20 |
71 (9) |
72 (7) |
N/R |
1301 (621) |
1744 (804) |
0.002 |
N/R |
N/R |
||
|
Molloy, 2007[19] |
50 |
50 |
N/R |
N/R |
N/R |
N/R |
N/R |
1225 (499) |
1415 (416) |
0.041 |
5 |
11 |
0.79 |
|
|
Kakar 2009[4]‡ |
12 |
12 |
25 |
33 |
62.4 (9.4), |
66.2 (4.8) |
67.9 (10.8) |
63.4 (7.2) |
160 (87) |
270 (88) |
<0.05 |
N/R |
N/R |
|
|
Wong, 2010[11] □ |
64 |
35 |
19, 42 □ |
37 |
67 (11.9), 63.9 (10.6) |
68.4 (10.4) |
82.0 (15.6), 81.8 (14.7) |
87.9 (19.2) |
1295 (353.7), 1208 (376.0) |
1610 (378.6) |
0.0001 |
1, 0 |
2 |
0.083 |
|
Ishida, 2011[43] |
50 |
50 |
12 |
12 |
73.3 (5.0) |
73.5 (6.1) |
59.7 (9.0) |
59.7 (10.1) |
N/R |
N/R |
0 |
1 |
N/R |
|
|
Sa-ngasoongsong, 2011[24] |
24 |
24 |
78 |
82 |
69.0 (8.2) |
69.2 (7.6) |
N/R |
N/R |
206.3 (115.4) |
385.1 (145.2) |
<0.0001° |
1 |
8 |
0.023 |
| Roy, 2012[37] | 25 | 25 | 40 | 36 | 66.04 (7.15) | 66.56 (8.03) | N/R | N/R | **** 109.6 ± 71.54 + 401 ± 82.44 | **** 194 ± 79.66 + 870 ± 201.04 | N/R | 2 | 7 | Not Significant |
* - Weighted Mean Value7, † - Calculated from 95% CI, § Average, SD – Standard Deviation, C – Control group, TXA – Tranexamic acid group, ◊ - Median Value, DVT – deep venous thrombosis, ** (Patients received pre-op TXA, patients received intra-op TXA, patients received both pre + intra op TXA), ‡ - Unilateral TKA data reported only, □ - (Patients received 1.5 gm TXA, patients received 3 gm TXA), *** (Patients received TXA bolus + long IV, patients received TXA bolus + short IV, patients received oral TXA), N/R – not reported. **** Sum of per-operative and drain collection. ↑Patients received TXA prior to tourniquet deflation, an additional preoperative dose, an additional postoperative dose, all three doses, or locally.