Table 4.
Patient characteristics - hip
|
Study, Year |
Number of patients TXA/C |
Gender distribution % male TXA /C |
Mean age TXA,C (SD or range) |
Mean weight (kg) – TXA, C (SD or Range) |
TBL – TXA,C (mL) (SD) |
P Value |
Patient requiring allogeneic transfusions (TXA, C) |
P Value |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TXA | C | TXA | C | TXA | C | TXA | C | TXA | C | TXA | C | |||
|
Ekbäck, 2000[28] |
20 |
20 |
45 |
55 |
66.4 (9.0) |
65.6 (8.8) |
81.1 (13) |
76.8 (13) |
1130 (400) |
1770 (523) |
<0.001 |
5 |
5 |
N/R |
|
Benoni, 2000[29] |
20 |
19 |
30 |
58 |
69.5 (10) |
68 (10) |
76 (14), |
77 (11) |
990 ◊(210 ), |
950 ◊(162.5) |
N/R |
45 |
79 |
0.05 |
|
Benoni, 2001[33] |
18 |
20 |
50 |
50 |
66 (9.5) |
68 (9.4) |
79 (16) |
78 (17) |
759 (275.8†) |
996 (398†) |
0.03 |
22 |
40 |
0.2 |
|
Husted, 2003[25] |
20 |
20 |
35 |
30 |
65 |
67 |
N/R |
814 (1323.8†) |
1231 (1692.7†) |
0.001 |
10 |
35 |
0.04 |
|
|
Yamasaki, 2004[41] |
20 |
20 |
95 |
90 |
55.5 (14.2) |
61.2 (6.9) |
52.6 (11.5) |
54.5 (8.7) |
1350 (477) |
1667 (401) |
<0.05 |
0 |
0 |
N/R |
|
Garneti, 2004[14] |
25 |
25 |
N/R |
69.6 (11.99) |
67.6 (11.4) |
N/R |
1443 (809) |
1340 (665) |
0.822 |
64 |
56 |
N/R |
||
|
Lemay, 2004[34] |
20 |
19 |
60 |
68 |
59.7 (10.3) |
53.6 (12.8) |
80.1 (15.7) |
74.7 (14.1) |
1308 (462) |
1469 (405) |
N/R |
0 |
42 |
0.0012 |
|
Johansson, 2005[26] |
47 |
53 |
53 |
53 |
69 (7) |
69 (7) |
81 (16) |
78 (13) |
969 (434) |
1324 (577) |
<0.001 |
17 |
43 |
0.009 |
|
Niskanen, 2005[30] |
19 |
20 |
32 |
35 |
66 (9.1) |
65 (8.2) |
80 (19) |
82 (14) |
792 (390.1†) |
1102 (485.2 †) |
0.03 |
26 |
40 |
0.3 |
|
Claeys, 2007[32] |
20 |
20 |
25 |
35 |
73 (8) |
68 (11) |
76 (15) |
72 (16) |
801 (244) |
1038 (289) |
0.013 |
5 |
30 |
<0.05 |
|
Kazemi, 2010[8] |
32 |
32 |
72 |
63 |
46.6 (16.2) |
45.4 (17.2) |
72.1 (10.4), |
69.9 (11.1) |
1024 (544) |
1399 (587) |
0.024 |
N/R |
N/R |
|
|
Malhotra, 2011[20] |
25 |
25 |
40 |
48 |
52.6 (39–72) |
54.7 (40–71) |
80.2 (58–100) |
81.9 (62–98) |
410 (300–510) – range |
615 (515–750) –range |
<0.5 |
24 |
72 |
N/R |
|
McConnell, 2011[38] |
22 |
22 |
32 |
41 |
N/R |
N/R |
N/R |
N/R |
930 (399†) |
1200 (469†) |
0.02 |
0 |
0 |
N/R |
| Imai, 2012[39]* | 24, 20, 25, 26 | 22 | 17, 20, 16, 15 | 23 | 64.4 (49–74), 62.2 (50–85), 63.3 (47–80), 63.3 (48–81) | 60.2 (54–72) | 55.9 (44–86), 54.1 (40–76), 54.1 (41–70), 53.8 (44–73) | 56.3 (47–80) | 649, 566, 388, 418** | 1026** | N/R | 0 | 0 | N/R |
◊Sum of perioperative and drain medians7, † - Calculated from 95% CI, C – Control group, TXA – Tranexamic group, SD – Standard Deviation, DVT – deep venous thrombosis, N/R – not reported. *Patients received 1 g TXA 10 minutes prior to skin closure, 10 minutes prior to skin closure and 6 hrs later, 10 minutes prior to surgery, 10 minutes prior to surgery and 6 hrs later, respectively. ** Intra-op + post-op.