Table 2.
Odds ratios
| Controls | SCC Cases | Controls | BCC Cases | Controls | Early-onset BCC Cases | Controls | Multiple BCC Cases | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | N (%) | OR1 (95% CI) | N (%) | N (%) | OR1 (95% CI) | N (%) | N (%) | OR1 (95% CI) | N (%) | N (%) | OR1 (95% CI) | |
| Photosensitizing medications | ||||||||||||
| No use | 1385 (72.7) | 1062 (66.5) | 1.0 (ref) | 1256 (85.2) | 1303 (83.2) | 1.0 (ref) | 760 (87.8) | 514 (76.4) | 1.0 (ref) | 1256 (85.2) | 181 (71.2) | 1.0 (ref) |
| Ever use | 521 (27.3) | 536 (33.5) | 1.2 (1.0–1.4) | 219 (14.8) | 264 (16.8) | 1.2 (0.9–1.5) | 106 (12.2) | 159 (23.6) | 1.5 (1.1–2.1) | 219 (14.8) | 74 (28.8) | 1.4 (1.0–2.1) |
| Phototoxic medications | ||||||||||||
| No use | 1385 (75.8) | 1062 (69.9) | 1.0 (ref) | 1256 (87.8) | 1303 (86.1) | 1.0 (ref) | 760 (90.0) | 514 (79.3) | 1.0 (ref) | 1256 (87.8) | 181 (754) | 1.0 (ref) |
| Ever use | 441 (24.2) | 458 (30.1) | 1.1 (0.9–1.4) | 174 (12.2) | 211 (13.9) | 1.1 (0.9–1.5) | 84 (10.0) | 134 (20.7) | 1.5 (1.1–2.1) | 174 (12.2) | 59 (24.6) | 1.4 (0.9–2.1) |
| Antimicrobial medications | ||||||||||||
| No use | 1385 (96.0) | 1062 (95.2) | 1.0 (ref) | 1256 (97.1) | 1303 (93.5) | 1.0 (ref) | 760 (96.3) | 514 (88.5) | 1.0 (ref) | 1256 (97.1) | 181 (94.3) | 1.0 (ref) |
| Ever use | 57 (4.0) | 54 (4.8) | 1.4 (0.9–2.1) | 38 (2.9) | 90 (6.5) | 1.9 (1.3–2.8) | 29 (3.7) | 67 (11.5) | 2.1 (1.3–3.5) | 38 (2.9) | 11 (5.7) | 1.6 (0.7–3.5) |
| Tetracyclines | ||||||||||||
| No use | 1385 (97.0) | 1062 (97.3) | 1.0 (ref) | 1256 (97.5) | 1303 (94.4) | 1.0 (ref) | 760 (96.8) | 514 (89.5) | 1.0 (ref) | 1256 (97.5) | 181 (96.3) | 1.0 (ref) |
| Ever use | 43 (3.0) | 29 (2.7) | 1.0 (0.6–1.7) | 32 (2.5) | 77 (5.6) | 1.8 (1.2–2.8) | 25 (3.2) | 60 (10.5) | 2.0 (1.2–3.4) | 32 (2.5) | 7 (3.7) | 1.2 (0.5–2.9) |
| Cardiovascular medications | ||||||||||||
| No use | 1385 (87.7) | 1062 (81.0) | 1.0 (ref) | 1256 (96.2) | 1303 (96.9) | 1.0 (ref) | 760 (97.9) | 514 (96.4) | 1.0 (ref) | 1256 (96.2) | 181 (91.9) | 1.0 (ref) |
| Ever use | 195 (12.3) | 249 (19.0) | 1.3 (1.0–1.6) | 49 (3.8) | 41 (3.1) | 0.8 (0.5–1.3) | 16 (2.1) | 19 (3.6) | 1.7 (0.8–3.6) | 49 (3.8) | 16 (8.1) | 1.2 (0.6–2.3) |
1
Adjusted by age, sex, number of painful sunburns, and study phase in final models; other confounder effects including the lifetime hours of warm months sun exposure, skin response to first hour of sun in summer, tanning lamp use and radiation treatment did not alter estimates of photosensitizing medications effects and were not included in final models.