. Author manuscript; available in PMC: 2013 Oct 1.

Published in final edited form as: Clin Rev Allergy Immunol. 2013 Oct;45(2):170–179. doi: 10.1007/s12016-012-8346-7

Table 4.

Pharmacogenetics of biologics^a

Drug	Gene	Variant	Clinical effects
Anti-TNF agents	TNF	G308A	Increased efficacy in most studies
	TNF	A238G	Increased efficacy
	TNFRSF1B	T196G	Decreased or no effect on efficacy
	FCGR3A	Val158Phe	No effect on efficacy
	PTPRC	SNP	Increased efficacy
	MAPK14	SNP	Increased efficacy of anti-TNF antibodies (infliximab, adalimumab)
Rituximab	FCGR3A	Val158Phe	Increased efficacy or no effect

See text for abbreviations and further explanations. Large gene signature studies are not included