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. 1988 Oct;8(10):4533–4536. doi: 10.1128/mcb.8.10.4533

Efficiency of translation initiation by non-AUG codons in Saccharomyces cerevisiae.

J M Clements 1, T M Laz 1, F Sherman 1
PMCID: PMC365530  PMID: 3141793

Abstract

The quantitative levels of initiation of protein synthesis at codons other than AUG were determined with a CYC7-lacZ fused gene in the yeast Saccharomyces cerevisiae. AUG was the only codon which efficiently initiated translation, although some non-AUG codons allowed initiation at very low efficiency, below 1% of the normal level. Since translation initiates at codons other than AUG in at least two wild-type genes from eucaryotes, other factors presumably play a role in enhancing the activity of non-AUG codons.

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Selected References

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