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. 2012 Jul 2;32(19):2463–2474. doi: 10.1038/onc.2012.256

Figure 6.

Figure 6

STAT5 phosphorylation is attenuated in p110 t-ERBB2-expressing cells, and elicits migration and invasion of HMLE cells. (a) Western blot of phospho-STAT5 in lysates from recombinant HMLE cells expressing ERBB2 isoforms. (b) Western blot of phospho-STAT5 in lysates from recombinant HME cells expressing ERBB2 isoforms. (c) Western blot of p21 in lysates from recombinant HMLE cells expressing ERBB2 isoforms. (d) Western blot of total STAT5 protein in lysates from HMLE transduced with non-silencing control (NSC) shRNA or STAT5-targeted shRNA. (e) Migration (left panels) and invasion (right panels) of control HMLE (top rows) and HMLE with silenced STAT5 expression (bottom rows) from (d).