Table 4. Logistic and Cox regression analysis for identification of factors associated with ERG+ status.
Factor | OR | 95% CI | P-value |
---|---|---|---|
Logistic regression—univariate | |||
Age quartile 1 | 1.81 | 1.35–2.44 | 0.000* |
Age quartile 2 | 1.18 | 0.91–1.56 | 0.260 |
Age quartile 3 | 0.90 | 0.71–1.20 | 0.460 |
Age quartile 4 | 0.53 | 0.40–0.70 | 0.000* |
PSA range <4 | 1.65 | 1.23–2.22 | 0.001* |
PSA range 4–10 | 0.68 | 0.52–0.91 | 0.007* |
PSA range ⩾10 | 0.87 | 0.59–1.30 | 0.501 |
GS group <7 | 0.91 | 0.71–0.11 | 0.446 |
GS group =7 | 1.31 | 1.02–1.69 | 0.030* |
GS group >7 | 0.65 | 0.44–0.96 | 0.290 |
Logistic regression—multivariate step 1 | |||
GS group >7 | 1.00 | ------------- | 0.27 |
GS group <7 | 1.13 | 0.62–2.07 | 0.69 |
GS group =7 | 1.45 | 0.84–2.51 | 0.18 |
PV, ml | 0.99 | 0.97–1.00 | 0.05 |
PSA range ⩾10 | 1.00 | 0.58 | |
PSA range <4 | 0.77 | 0.40–1.49 | 0.43 |
PSA range 4–10 | 0.72 | 0.39–1.33 | 0.30 |
Age quartile 4 | 1.00 | ------------- | 0.05 |
Age quartile 1 | 2.03 | 1.17–3.50 | 0.01* |
Age quartile 2 | 1.41 | 0.87–2.28 | 0.17 |
Age quartile 3 | 1.07 | 0.66–1.75 | 0.78 |
fPSA% | 0.99 | 0.96–1.02 | 0.65 |
Logistic regression—multivariate final backward step 4 | |||
Age quartile 4 | 1.00 | ------------- | 0.036* |
Age quartile 1 | 2.05 | 1.22–3.44 | 0.007* |
Age quartile 2 | 1.42 | 0.89–2.28 | 0.146 |
Age quartile 3 | 1.01 | 0.67–1.76 | 0.673 |
PV, ml | 0.99 | 0.99–1.00 | 0.031* |
Cox regression (inclusion model) | |||
RR | 95% CI | P-value | |
ERG+ | 1.25 | 1.09–1.44 | 0.001* |
PSA | 0.96 | 0.94–0.97 | <0.001* |
Abbreviations: CI, confidence interval; GS, gleason score; OR, odds ratio; PV, prostate volume.
*P<0.05.
Multivariate logistic regression was performed using a stepwise backward elimination model. OR values of 1.00 indicate reference values with no CI computable. Data of the first and the last steps are shown. For Cox regression the inclusion model was applied.