Skip to main content
. Author manuscript; available in PMC: 2013 May 16.
Published in final edited form as: J Urol. 2011 Feb 19;185(4):1478–1483. doi: 10.1016/j.juro.2010.11.091

Figure 1. Release of paclitaxel from PNP.

Figure 1

(A) In vitro release of paclitaxel from PNP (1 to 50 μg/ml paclitaxel-equivalent) in PBS. Data are mean + 1 SD (n=3). Note that SD are smaller than symbols. (B) Release of paclitaxel in urine of tumor-free dogs given a dose of intravesical PNP (1 mg/20 ml paclitaxel-equivalent). Note the break in the y axis. Over the 2-hr treatment, the volume of urine increased from 20 to 28 ml and the total concentration (PNP-bound and free drug) declined from 50 to 34 μg/ml, whereas the free paclitaxel concentrations remained relatively constant at 1.18-1.36 μg/ml. Data are mean + 1 SD (n=8).