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. Author manuscript; available in PMC: 2013 May 16.
Published in final edited form as: J Urol. 2011 Feb 19;185(4):1478–1483. doi: 10.1016/j.juro.2010.11.091

Figure 3. Bladder tissue pharmacokinetics of paclitaxel in tumor-free dogs given intravesical PNP.

Figure 3

Animals were given a single dose of intravesical PNP (1 mg/20 ml paclitaxel-equivalent). Bladders were removed at predetermined times, frozen and cryo-sectioned. The first two sections (40 μm) were discarded to avoid contamination of tissue by urine that contained high drug concentrations. Drug concentrations in tissue sections were analyzed by ELISA. Total paclitaxel concentrations as a function of tissue depth, at five time points, i.e., 4, 8, 24, 72 and 168 hr after initiation of the 2-hr treatment. Data are mean values (n=3 per group). The average SD was 68% (range 6-180%, median: 61%) of the mean values (not shown).