. Author manuscript; available in PMC: 2013 May 16.

Published in final edited form as: J Urol. 2011 Feb 19;185(4):1478–1483. doi: 10.1016/j.juro.2010.11.091

Table 1.

Systemic bioavailability of paclitaxel in tumor-free dogs given an intravesical dose of PNP (1 mg/20 ml).

Literature data on paclitaxel clearance in other species, median (range), l/hr*kg	Calculated systemic bioavailability in dogs using clearance values in other species (%)
	0-4 hr	4-8 hr	0-8 hr

Mice: 0.301 (0.15-0.56) ^17,18	0.60	0.35	0.95
Rats: 0.366 (0.243-0.837) ^19-21	0.73	0.43	1.16
Humans: 0.430 (0.296-0.577) ²²	0.84	0.50	1.35

Systemic bioavailability in dogs was calculated using the plasma data shown in Figure 2 and the median values of the clearance of paclitaxel (formulated in Cremophor micelles) in rodents and humans. This was necessary because the clearance in dogs has not been studied due to the severe Cremophor hypersensitivity in this species. The AUC in dogs was 119.2 ng*min/ml from 0-4 hr, 70.3 ng*min/ml from 4-8 hr, and 189.5 ng*min/ml from 0-8 hr.